Wednesday, August 30th |
|
| 15.00-18.00 | Registration at Festetics Palace |
| 18.00-18.10 | Welcome address: Miklós Geiszt |
| 18.10-19.10 | OL Opening Lecture: Michael Davies: CHLORINATION AND NITRATION BY MYELOPEROXIDASE IN CARDIOVASCULAR DISEASE |
| 19.10-21.00 | Welcome Reception |
Thursday, August 31st |
|
| 9.00-10.55 | Session I: Enzymology of mammalian peroxidases - Chair: William M. Nauseef |
|
9.00-9.25 +5' disc. |
O-1 Christian Obinger: HUMAN HEME PEROXIDASES - WHAT DO THEY HAVE IN THEIR HEME POCKET? |
|
9.30-9.55
+5' disc. |
O-2 Martina Paumann-Page: PEROXIDASIN AS A MODULATOR OF CANCER CELL INVASION |
|
10.00-10.20
+5' disc. |
O-3 Vera Pfanzagl: FIRST CRYSTAL STRUCTURE OF EOSINOPHIL PEROXIDASE REVEALS SUBTLE DISTINCTIONS IN THE ACTIVE SITE ARCHITECTURE AND PROCESSING |
|
10.25-10.50
+5' disc. |
O-4 Paul Furtmüller: REACTIVITY AND PROTEIN-PROTEIN INTERACTION OF HUMAN PEROXIDASIN 1 |
| 10.55-11.20 | Coffee break |
| 11.20-13.05 | Session II: Hydrogen peroxide sources supporting mammalian peroxidases - Chair: Albert van der Vliet |
|
11.20-11.45 +5' disc. |
O-5 Thomas L. Leto: DUOX1 INVOLVEMENT IN FUNGAL PATHOGEN SUSCEPTIBILITY: HUMAN VARIANTS LINKED TO ALTERED PATHOGEN SENSING AND RESPONSE |
|
11:50–12:10
+5' disc. |
O-6 Anna Pató: AQUAPORIN 3: A POTENTIAL HYDROGEN PEROXIDE TRANSPORTER IN EPITHELIAL CELLS |
|
12.15-12.35
+5' disc. |
O-7 Beáta Scholtz: SUPPRESSION OF THE HUMAN COLONIC NADPH OXIDASE 1 THROUGH POST-TRANSCIPTIONAL MECHANISMS |
|
12.40-13.00
+5' disc. |
O-8 Deepak Rathi: EFFECT OF EXOSOMAL TREATMENT ON NOX4 EXPRESSION IN MONOCYTES AND MACROPHAGES |
| 13.10-14.10 | Lunch |
| 14.10-16.30 | Session III: Chemistry and biochemistry of oxidation products - Chair: Christian Obinger |
|
14.10-14.35 +5' disc. |
O-9 Clare Hawkins: OXIDATIVE MODIFICATION OF HISTONES IN “NETS” – A NEW DRIVER OF CELLULAR DYSFUNCTION IN CHRONIC INFLAMMATION? |
|
14.40-15.00 +5' disc. |
O-10 Joshua Chandler: SEARCHING FOR CANDIDATE BIOMARKERS OF HYPOTHIOCYANOUS ACID EXPOSURE IN CELL CULTURE |
|
15.05-15.30 +5' disc. |
O-11 Steven Rokita: WHY NATURE DEHALOGENATES HALOTYROSINES |
| 15.35-15.55 | Coffee break |
|
15.55-16.15 +5' disc. |
O-12 Grace Borichevsky: TAURINE CHLORAMINE PROMOTES UNUSUAL PATTERNS OF CROSS-LINKS IN CALPROTECTIN |
|
16.20-16.45 +5' disc. |
O-13 Péter Nagy: INTERACTIONS OF REACTIVE SULFUR SPECIES WITH HUMAN PEROXIDASES |
Friday, September 1st |
|
| 9.00-10.45 | Session IV: Physiological and pathophysiological roles of mammalian peroxidases I. - Chair: Thomas L. Leto |
|
9.00-9.20 +5' disc. |
O-14 Wyllie Kaitlin: THE ROLE OF PEROXIDASIN IN CANCER DISEASE PROGRESSION |
|
9.25-9.50
+5' disc. |
O-15 Martin Mollenhauer: ”FROM THE OUTSIDE TO THE INSIDE”: MYELOPEROXIDASE IMPACTS VASCULAR FUNCTION BY ALTERING PERIVASCULAR ADIPOCYTES’ PHENOTYPE IN OBESITY |
|
9.55-10.15
+5' disc. |
O-16 Gábor Sirokmány: IDENTIFICATION OF THE POSTTRANSLATIONAL MODIFICATIONS OF THE C-TERMINAL DOMAIN OF HUMAN PEROXIDASIN |
|
10.20-10.40
+5' disc. |
O-17 Cecilia Tangeten: INFLUENCE OF MYELOPEROXYDASE OXIDIZED-LDLS ON SPECIALIZED PRO-RESOLVING MEDIATORS PRODUCTION |
| 10.45-11.10 | Coffee break |
| 11.10-12.55 | Session V: Translational aspects of peroxidase research - Chair: Clare Hawkins |
|
11.10-11.35
+5' disc. |
O-18 William Nauseef: SPECIFIC MUTATION IN STAPHYLOCOCCUS AUREUS SUPPORTS GAIN OF FUNCTION IN SUSCEPTIBILITY TO HOCL AND HUMAN NEUTROPHILS |
|
11.40-12.00
+5' disc. |
O-19 Jenny Shapiro: MYELOPEROXIDASE KO IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION |
|
12.05-12.25
+5' disc. |
O-20 Marie van der Gucht: NOVEL PLATFORM TO PRODUCE PHARMACEUTICAL PEROXIDASES EMPLOYING AI-BASED PREDICTION MODELS AND INVESTIGATIONS |
|
12.30-12.50
+5' disc. |
O-21 Balázs Rada: TREATMENT WITH THE PEROXIDASE SUBSTRATE THIOCYANATE REDUCES MORTALITY IN INFLUENZA INFECTION |
| 13.00-14.00 | Lunch |
| 14.00-15.30 | Poster Session |
| 15.30-17.10 | Session VI: Physiological and pathophysiological roles of mammalian peroxidases II. - Chair: Mark Hampton |
|
15.30-15.55 +5' disc. |
O-22 Albert van der Vliet: CONCERTED ROLES FOR DUAL OXIDASE 1 (DUOX1) AND PEROXIDASIN (PXDN) IN OXIDATIVE ECM REMODELING IN PULMONARY FIBROSIS |
|
16.00-16.20 +5' disc. |
O-23 Pierre van Antwerpen: MONITORING OF MPO-DEPENDENT OXIDATION OF LDL AND HDL IN SERUM – WHAT DO WE LEARN? |
|
16.25-16.45 +5' disc. |
O-24 Karen Yang-Jensen: HUMAN ATHEROSCLEROTIC LESIONS CONTAIN OXIDANT-MODIFIED MYELOPEROXIDASE AND EXTRACELLULAR MATRIX |
|
16.50-17.10 +5' disc. |
O-25 Yasuaki Aratani: MICE DEFICIENT IN NOX2 DISPLAY AN ENHANCED GRANULOPOIESIS AND REDUCED LYMPHOPOIESIS IN A ZYMOSAN-INDUCED INFLAMMATION MODEL |
|
19.30-23.00 |
Conference Dinner and Jazz Concert at the Festetics Palace |
Saturday September 2nd |
|
| 9.00- 10.45 | Session VII: Physiological and pathophysiological roles of mammalian peroxidases III. - Chair: Gábor Sirokmány |
|
9.00-9.25 +5' disc. |
O-26 Mark Hampton: SENSITIZING PATHOGENIC BACTERIA TO OXIDANTS GENERATED BY THE INNATE IMMUNE SYSTEM |
|
9.30-9.50
+5' disc. |
O-27 Alexander Kostyuk: DEVELOPMENT OF IMPROVED GENETICALLY ENCODED BIOSENSORS FOR THE VISUALIZATION OF (PSEUDO)HYPOHALOUS ACIDS IN CELLS AND LIVING ORGANISMS |
|
9.55-10.15
+5' disc. |
O-28 Michael Smith: LARGE OPEN-LABEL “STUDY” DEMONSTRATES DIETARY IODINE ACTIVATES THE LACTOPEROXIDASE DEFENSE AGAINST PANDEMIC AIRBORNE MICROBES |
|
10.20-10.40
+5' disc. |
O-29 Alexey Sokolov: LACTOFERRIN PREVENTS HALOGENATIVE AND OXIDATIVE STRESS AND PROMOTES WOUND HEALING IN RATS WITH EXPERIMENTAL HYPERGLYCEMIA |
| 10.45-11.10 | Coffee break |
| 11.10-12.25 | Session VIII: Design and application of peroxidase inhibitors - Chair: Péter Nagy |
|
11.10-11.30
+5' disc. |
O-30 Christine Chuang: HEPARIN AND ANALOGUES DECREASE MYELOPEROXIDASE BINDING TO EXTRACELLULAR MATRIX AND MODULATE ITS ENZYMATIC ACTIVITY |
|
11.35-11.55
+5' disc. |
O-31 Yalda Parsajoo: IMMOBILIZATION OF HUMAN MYELOPEROXIDASE ON SILICA GEL FOR INHIBITOR DETECTION |
|
12.00-12.20
+5' disc. |
O-32 Urban Leitgeb: THE INHIBITORY PROTEIN SPIN REDUCES THE HALIDE OXIDATION RATE OF MYELOPEROXIDASE BUT LEAVES THE SUBSTRATE BINDING SITE UNAFFECTED |
|
12.25-12.30
|
Closing remarks: Miklós Geiszt |
| 12.30-13.30 | Lunch |
List of Posters |
|
| P-01 | Paul Furtmüller :MOLECULAR PHYLOGENY OF HEME PEROXIDASES FROM CEPHALOCHORDATA |
| P-02 | Noémi Szántó :ROLE OF SELENOENZYMES IN THE REDUCTION OF PERSULFIDE SPECIES |
| P-03 | Andrea Domán :LACTOPEROXIDASE CATALYTICALLY OXIDIZES HYDROGEN SULFIDE VIA INTERMEDIATE FORMATION OF SULFHEME DERIVATIVES |
| P-04 | Bianca Parzer :RECONSTITUTION AND LINKAGE OF HEME IN THYROID PEROXIDASE POST-PURIFICATION |
| P-05 | Alexey Sokolov :METHOD FOR REGISTRATION THE MYELOPEROXIDASE BROMINATING ACTIVITY USING FLUORESCEIN |
| P-06 | Clare Hawkins :CHARACTERISATION OF EXTRACELLULAR TRAPS RELEASED BY MACROPHAGES: A CONTRIBUTING FACTOR TO LESION FORMATION IN ATHEROSCLEROSIS? |
| P-07 | Bernadett Balázs :INVESTIGATION LACTOPEROXIDASE FUNCTION USING A GENE-DEFICIENT MOUSE STRAIN |
| P-08 | Zsolt Szeles :DETECTION OF NADPH OXIDASE 5 (NOX5) PROTEIN EXPRESSION IN HUMAN CELLS AND TISSUES |
| P-09 | Lilla Bodrogi :ESTABLISHMENT OF A PXDNL KNOCK-OUT RABBIT MODEL |
| P-10 | Filipp Terzer :TESTING THE INCORPORATION EFFICIENCY OF PHENYLALANINE DERIVATIVES WITH A DUAL FLUORESCENT REPORTER PROTEIN |